Requests for change are now submitted directly into eSirius 3G like an amendment. The only difference is that RFCs undergo verification, which is generally quicker than the review and approval process. The IACUC Office will determine whether your amendment meets the conditions for an RFC.
The IACUC SOPs below provide guidance on whether a modification can be added by a Request for Change. If the modification is outside the SOP, then an amendment must be submitted.