Laboratory Inspections


Semi-Annual Inspections
 
Why am I being inspected?
Both the PHS Policy (IV,B,1; IV,B,2) and the AWAR (§2.31,c,1; §2.31,c,2) require the IACUC to inspect animal facilities at intervals of no less than six months.
 
Only certain activities are considered inspectable. Only animal rooms that meet one or more of the following criteria will be inspected:
  • Locations where survival and/or non-survival surgery are performed
  • Locations where animals are housed outside of UAC for >24 hours (satellite facility)
  • Locations where USDA-regulated species are used (includes >12 hour housing)
If your room usage has changed (i.e., no longer performing surgery in that location), notify the IACUC Office so that we can remove the use location from the list of inspectable locations.
 
When does it occur?
Semi-annual IACUC inspections generally occur in April and October.
 
The PI and protocol contacts will receive an email announcing the inspection approximately three weeks before the date of the inspection. The PI must contact the IACUC Office immediately if the proposed time and/or date is unsuitable. Please note that the IACUC inspectors have a limited time available for the inspection. If at all possible, delegate senior laboratory personnel with good knowledge of the animal protocols to be present during the inspection rather than ask for the inspection to be rescheduled.

What to expect at the inspection
 
IACUC inspectors will arrive at the animal use location sometime within the inspection window. One or more IACUC inspectors will be present and there may be additional inspectors or observers.
 
Inspectors will observe the animal use location and will ask questions of the personnel present. Ensure that at least one senior member who is both knowledgeable about and is listed on all the animal protocols is present in the animal use location before the inspection begins. Inspectors may have difficulty locating personnel if they are in offices or other work spaces, which delays the inspection.
 
Inspectors are required to complete an IACUC Facility Inspection Form during the inspection period. Items that are commonly overlooked by the research staff when preparing for inspection are as follows:
 
Access to animal protocols
The inspectors ask if all protocol participants have access to the approved protocols and amendments. Printed copies of all approved protocols and amendments can be maintained in the laboratory. However, it is important that these document are kept up-to-date. Remember that all approved protocols and amendments are available in eSirius and that all protocol participants have access to these documents in eSirius.
 
Emergency, weekend and holiday care numbers
These numbers should be posted in a high traffic area, such as the near the lab door. A form that can be completed and taped to the door/wall is available on the IACUC Forms page.
 
Animal husbandry SOPs and care logs (if the animals are housed for more than 24 hours)
The inspectors will look to see if there are printed copies of animal husbandry SOPs and completed animal care logs available in the laboratory. Sample forms are available on the IACUC Forms page.
 
Permits for wildlife protocols
Please have these available for inspection. If they are locked in someone's office or in a separate location, please ensure that you have the permit or a copy available at the time of the inspection.
 
Surgical and analgesia records
If your animal protocol lists surgery or requires palliative therapy for non-surgical procedures, please ensure that surgery and analgesia records are available for inspection. Sample forms can be found on the IACUC Forms page.
 
Drugs, including controlled substances
Inspectors will look at drugs listed on the protocol. Please ensure that keys to access controlled substances are available at the time of the inspection. This includes any keys required to get into offices or other rooms where the drugs are kept. Ensure that all expired drugs are discarded or in the case of controlled substances, clearly marked and kept separate from the non‑expired drugs.

PAM inspections
 
Post Approval Monitoring (PAM) is a program to review IACUC approved protocols to ensure both animal research best practices and institutional regulatory compliance by allowing a more thorough inspection of individual labs and animal related procedures. The PAM monitor works with investigators to facilitate their animal research and to be proactive in identifying potential problems in their compliance with active animal protocols.
 
PAM monitoring may occur during the approval period for any animal protocol.

AAALAC inspections
 
AAALAC inspections occur once every three years as part of the University's Animal Care and Use accreditation. The notification of an AAALAC inspection is similar to that for the IACUC semi-annual inspection and the inspection process is also similar.
 
The next AAALAC inspection will be conducted on October 3-6, 2016.
Contact the
IACUC Office 
 
 
626-5304
Protocol amendments
Memoranda of understanding
Continuing reviews
Expiring protocols
Semi-annual lab inspections
Post-approval monitoring
Welfare and non-compliance
 
626-1247
New protocol submissions
eSirius
Issues with web forms

626-9071
Personnel Amendments
CITI training

     
     Report Misconduct
Ethics Hotline


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